FITC标记的神经突出相关蛋白Slitrk1抗体
产品名称： FITC标记的神经突出相关蛋白Slitrk1抗体
英文名称： Anti-Slitrk1/FITC
产品编号： HZ-6192R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-Slitrk1/FITC Conjugated antibody
FITC标记的神经突出相关蛋白Slitrk1抗体
| 英文名称 | Anti-Slitrk1/FITC |
| 中文名称 | FITC标记的神经突出相关蛋白Slitrk1抗体 |
| 别 名 | SLITRK 1; KIAA0918; KIAA1910; Leucine rich repeat containing protein 12; SLITRK 1; LRRC1; SLIT and NTRK like family, member 1. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 神经生物学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 76kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Slitrk1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Slitrk1 is a member of a protein family consisting of six homologous transmembrane proteins (Slitrk1-6) that share two conserved leucine-rich repeat domains in the extracellular domain and have significant homology to Slit, a secreted axonal growth-controlling protein. These proteins are also homologous to trk neurotrophin receptors in their intracellular domains. Expression of Slitrk proteins is highly restricted to neural and brain tumor tissues, but varies within the family. For example, Slitrk1 is expressed primarily in mature neurons. Overexpression of Slitrk1 in transfected neuronal cells induced unipolar neurites, while expression of the other Slitrk proteins inhibited neurite outgrowth, suggesting that these proteins are involved in the control of neurite outgrowth. While Slitrk1 variants have been suggested associated with Tourette’s Syndrome, it is thought to play only a minor role if at all. Function: Enhances neuronal dendrite outgrowth. Subcellular Location: Membrane; Single-pass type I membrane protein (Potential). Tissue Specificity: Expressed predominantly in the frontal lobe of the cerebral cortex of the brain. Also expressed in some astrocytic brain tumors such as astrocytomas, oligodendrogliomas, glioblastomas, gangliogliomas and primitive neuroectodermal tumors. DISEASE: Defects in SLITRK1 may be a cause of Gilles de la Tourette syndrome (GTS) [MIM:137580]. GTS is a neurologic disorder manifested particularly by motor and vocal tics and associated with behavioral abnormalities. Defects in SLITRK1 may be a cause of trichotillomania (TTM) [MIM:613229]. It is a neuropsychiatric disorder characterized by chronic, repetitive, or compulsive hair pulling resulting in noticeable hair loss. Affected individuals may develop physical complications and often have overlapping psychologic disorders, such as Gilles de la Tourette syndrome or obsessive-compulsive disorder. Similarity: Belongs to the SLITRK family. Contains 12 LRR (leucine-rich) repeats. Contains 2 LRRCT domains. Contains 2 LRRNT domains. Database links: Entrez Gene: 114798 Human Entrez Gene: 76965 Mouse Entrez Gene: 306147 Rat Omim: 609678 Human SwissProt: Q96PX8 Human SwissProt: Q810C1 Mouse Unigene: 415478 Human Unigene: 31034 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Slitrk基因编码一类跨膜蛋白,有6个家族成员,主要表达于神经系统,参与调节神经细胞突起生长 |
SLITRK1是由六个同源跨膜蛋白（SITRRK1-6）组成的蛋白家族的成员，其在胞外域中共享两个保守的富含亮氨酸的重复结构域，并与狭长的、具有分泌的轴突生长控制蛋白具有显著的同源性。这些蛋白也与Trk神经营养素受体在它们的胞内结构域上同源。SLITRK蛋白的表达高度受限于神经和脑肿瘤组织，但在家族内是不同的。例如，SLITRK1主要在成熟神经元中表达。SLITRK1在转染的神经元细胞中的过度表达诱导单极突起，而其他SLITRK蛋白的表达抑制突起生长，提示这些蛋白参与突起生长的控制。虽然SITRK1变异体被暗示与抽动秽语综合征相关，但被认为仅起次要作用。