PSENEN polyclonal antibody
产品名称： PSENEN polyclonal antibody
英文名称： PSENEN polyclonal antibody
产品编号： PAB13229
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of PSENEN.
- Immunogen:
- A synthetic peptide corresponding C-terminus to 13 amino acids of human PSENEN.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse, Rat
- Form:
- Liquid
- Storage Buffer:
- In PBS (0.02% sodium azide)
- Storage Instruction:
- Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Western Blot (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Functional reconstitution of gamma-secretase through coordinated expression of presenilin, nicastrin, Aph-1, and Pen-2.
Periz G, Fortini ME.J Neurosci Res. 2004 Aug 1;77(3):309-22.
- 2.
- Translating cell biology into therapeutic advances in Alzheimer's disease.
Selkoe DJ.Nature. 1999 Jun 24;399(6738 Suppl):A23-31.
- 3.
- The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease.
Selkoe DJ.Trends Cell Biol. 1998 Nov;8(11):447-53.
- Entrez GeneID:
- 55851
- Protein Accession#:
- NP_758844
- Gene Name:
- PSENEN
- Gene Alias:
- MDS033,MSTP064,PEN-2,PEN2
- Gene Description:
- presenilin enhancer 2 homolog (C. elegans)
- Omim ID:
- 607632
- Gene Ontology:
- Hyperlink
- Gene Summary:
- Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase. [provided by RefSeq
- Other Designations:
- hematopoietic stem/progenitor cells protein MDS033,presenilin enhancer 2
- Gene Pathway