FITC标记的液泡蛋白分选蛋白11抗体
产品名称： FITC标记的液泡蛋白分选蛋白11抗体
英文名称： Anti-VPS11/FITC
产品编号： HZ-12763R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-VPS11/FITC Conjugated antibody
FITC标记的液泡蛋白分选蛋白11抗体
| 英文名称 | Anti-VPS11/FITC |
| 中文名称 | FITC标记的液泡蛋白分选蛋白11抗体 |
| 别 名 | END1; HGNC:14583; hVPS11; PEP5; PP3476; RING finger protein 108; RNF108; Vacuolar protein sorting 11 (yeast homolog); Vacuolar protein sorting 11 (yeast); Vacuolar protein sorting 11 homolog (S. cerevisiae); Vacuolar protein sorting 11 homolog; Vacuolar protein sorting associated protein 11 homolog; Vacuolar protein sorting protein 11; Vacuolar protein sorting-associated protein 11 homolog; vps11; VPS11_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 信号转导 转运蛋白 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 108kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 2mg/1ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human VPS11 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human homolog of yeast class C Vps11 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014] Function: May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes. Subcellular Location: Late endosome membrane. Lysosome membrane. Cytoplasmic vesicle. Tissue Specificity: Ubiquitous. Expression was highest in heart and low in lung. Similarity: Belongs to the VPS11 family. Contains 1 clathrin repeat. Contains 1 RING-type zinc finger. Database links: Entrez Gene: 489374 Dog Entrez Gene: 55823 Human Entrez Gene: 71732 Mouse Entrez Gene: 315600 Rat Omim: 608549 Human SwissProt: Q9H270 Human SwissProt: Q91W86 Mouse Unigene: 234282 Human Unigene: 295013 Mouse Unigene: 2637 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
囊泡介导的蛋白质分选在细胞内分子分离成不同的细胞器方面起着重要作用。酵母的遗传学研究已经鉴定出40多个与囊泡转运到囊泡有关的空泡蛋白分选（VPS）基因。该基因编码酵母C类VPS11蛋白的人类同源物。哺乳动物C类Vps蛋白主要与晚期内切体/溶酶体相关，并且与它们的酵母对应物一样，可以介导内切体/溶酶体途径中的囊泡运输步骤。选择性剪接导致多个转录变体。[ RefSeq，FEB 2014 ]提供