FITC标记的阴离子交换蛋白2抗体
产品名称： FITC标记的阴离子交换蛋白2抗体
英文名称： Anti-AE2/FITC
产品编号： HZ-
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-AE2/FITC Conjugated antibody
FITC标记的阴离子交换蛋白2抗体
| 产品编号 | bs-9847R-FITC |
| 英文名称 | Anti-AE2/FITC |
| 中文名称 | FITC标记的阴离子交换蛋白2抗体 |
| 别 名 | AE 2; AE-2; AE2 anion exchanger; Anion exchange protein 2; Anion exchanger 2; B3A2_HUMAN; BND3L; EPB3L1; HKB3; MPB3L; Non-erythroid band 3-like protein; SLC4A2; Solute carrier family 4 member 2. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 心血管 细胞生物 通道蛋白 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 137kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human AE2/SLC4A2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Primary canalicular bile undergoes a process of fluidization and alkalinization along the biliary tract that is influenced by several factors, including hormones, innervation/neuropeptides and biliary constituents. The excretion of bicarbonate at both the canaliculi and the bile ducts is an important contributor to the generation of bile-salt independent flow. Bicarbonate is secreted from hepatocytes and cholangiocytes through parallel mechanisms, which involve chloride efflux through activation of chloride channels and further bicarbonate secretion via AE2 (also designated SLC4A2)-mediated chloride/bicarbonate exchange. The AE2 protein regulates pH, chloride concentration, cell volume and transepithelial ion transport in many tissues. Gene silencing of AE2 causes a marked inhibition of unstimulated and secretin-stimulated chloride/bicarbonate exchange, which maintains the bile acid pool that is crucial for secretin to induce bicarbonate-rich choleresis. Function: Plasma membrane anion exchange protein of wide distribution. Subcellular Location: Membrane. Similarity: Belongs to the anion exchanger (TC 2.A.31) family. Database links: Entrez Gene: 6522 Human Omim: 109280 Human SwissProt: P04920 Human Unigene: 647069 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
原发性小管胆汁经历了沿胆管的流化和碱化的过程，受多种因素的影响，包括、神经支配/神经肽和胆汁成分。在泪小管和胆管中碳酸氢盐的排泄是产生胆汁盐不独立流动的重要因素。碳酸氢盐通过平行的机制从肝细胞和胆管细胞分泌，这涉及通过激活氯离子通道和进一步碳酸氢盐分泌通过AE2（也被指定为SLC4A2）介导的氯化物/碳酸氢盐交换的氯离子流出。AE2蛋白在许多组织中调节pH、氯化物浓度、细胞体积和跨上皮离子转运。AE2基因沉默导致未刺激和分泌素刺激的氯化物/碳酸氢盐交换的显著抑制，维持胆汁酸池，这是分泌素诱导富含碳酸氢盐的胆汁淤积的关键。