FITC标记的胰岛素诱导基因2抗体
产品名称： FITC标记的胰岛素诱导基因2抗体
英文名称： Anti-Insig2/FITC
产品编号： HZ-6625R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-Insig2/FITC Conjugated antibody
FITC标记的胰岛素诱导基因2抗体
| 英文名称 | Anti-Insig2/FITC |
| 中文名称 | FITC标记的胰岛素诱导基因2抗体 |
| 别 名 | Hypothetical protein INSIG2; INSIG 2; INSIG-2; INSIG 2 membrane protein; INSIG2 membrane protein; Insulin induced gene 2; Insulin induced gene 2 protein; Insulin induced protein 2; MGC26273; INSI2_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 信号转导 转录调节因子 糖尿病 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 25kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Insig2 (81-130aa) |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Insig2 is highly similar to the protein product encoded by gene Insig1. Both Insig1 protein and Insig2 protein are endoplasmic reticulum proteins that block the processing of sterol regulatory element binding proteins (SREBPs) by binding to SREBP cleavage-activating protein (SCAP), and thus prevent SCAP from escorting SREBPs to the Golgi. Function: Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Seems to regulate the ubiquitin-mediated proteasomal degradation of HMGCR. Subunit: Binds to the SCAP-SREBF2 complex only in the presence of sterols. Interacts with RNF139. Subcellular Location: Endoplasmic reticulum membrane; Multi-pass membrane protein. Similarity: Belongs to the INSIG family. Database links: Entrez Gene: 51141 Human Entrez Gene: 72999 Mouse Entrez Gene: 288985 Rat Omim: 608660 Human SwissProt: Q9Y5U4 Human SwissProt: Q91WG1 Mouse SwissProt: Q80UA9 Rat Unigene: 7089 Human Unigene: 27136 Mouse Unigene: 486216 Mouse Unigene: 16736 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
IsIG2与由基因IsIG1编码的蛋白产物高度相似。IsIG1蛋白和IsIG2蛋白都是内质网蛋白，通过结合SREBP裂解激活蛋白（SCAP）阻断甾醇调节元件结合蛋白（SREBPS）的加工，从而防止SCAP从护送SRPPS到高尔基体。