FITC标记的原钙粘附蛋白α3抗体
产品名称： FITC标记的原钙粘附蛋白α3抗体
英文名称： Anti-PCDHA3/FITC
产品编号： HZ-11117R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-PCDHA3/FITC Conjugated antibody
FITC标记的原钙粘附蛋白α3抗体
| 产品编号 | bs-11117R-FITC |
| 英文名称 | Anti-PCDHA3/FITC |
| 中文名称 | FITC标记的原钙粘附蛋白α3抗体 |
| 别 名 | KIAA0345 like 11; PCDH alpha 3; Protocadherin alpha 3; PCDA3_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 神经生物学 信号转导 细胞粘附分子 细胞骨架 细胞外基质 细胞膜蛋白 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Horse, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 99kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human PCDHA3 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Protocadherins are a large family of cadherin-like cell adhesion proteins that are involved in the establishment and maintenance of neuronal connections in the brain. There are three protocadherin (PCDH) gene clusters, designated alpha, beta and gamma, all of which contain multiple tandemly arranged genes. The protein products of PCDH-alpha genes interact with Integrin ∫1 to promote cell adhesion and form oligomers with PCDH-gamma proteins at specific membrane sites. PCDHA3 (Protocadherin alpha-3) is a 950 amino acid single-pass transmembrane protein that contains six cadherin domains. PCDHA3 is a unique cadherin in that it likely functions in spermatogenesis and may also have a role in organizing germ cell-specific structures, such as the flagellum, acrosome and intercellular bridge. There are two isoforms of PCDHA13 that are produced as a result of alternative splicing events. Function: PCDHA3 contains six cadherin domains. It is thought to be a calcium dependent cell adhesion protein and may be involved in the establishment and maintenance of specific neuronal connections in the brain. There are two named isoforms. Subcellular Location: Cell membrane; Single pass type I membrane protein. Similarity: Contains 6 cadherin domains. Database links: Entrez Gene: 56145 Human Entrez Gene: 192163 Mouse Entrez Gene: 116780 Rat Omim: 606309 Human SwissProt: Q9Y5H8 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
原粘蛋白是一大类钙黏蛋白样细胞粘附蛋白，参与脑内神经元连接的建立和维持。共有三个原粘蛋白（PCDH）基因簇，命名为α、β和γ，它们都含有多个排列整齐的基因。PCDHα基因的蛋白产物与整合素1相互作用，促进细胞黏附，并在特定的膜部位形成具有PCDHγ蛋白的寡聚体。PCDHA3（原粘蛋白-AlpHA-3）是一个含有六个钙黏附蛋白结构域的950氨基酸单程跨膜蛋白。PCDHA3是一种独特的钙黏附蛋白，它可能在精子发生中起作用，也可能在组织生殖细胞特异性结构中起作用，如鞭毛、顶体和细胞间桥。作为替代剪接事件的结果，产生了两种PCDHA13异构体。