FITC标记的有丝分裂控制样蛋白DIS3L抗体
产品名称： FITC标记的有丝分裂控制样蛋白DIS3L抗体
英文名称： Anti-DIS3L/FITC
产品编号： HZ-9052R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
上海沪震实业有限公司
- 联系人 : 鲍丽雯
- 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
- 邮编 : 200612
- 所在区域 : 上海
- 电话 : 139****0749 点击查看
- 传真 : 点击查看
- 邮箱 : www.shzbio.net
- 二维码 : 点击查看
Rabbit Anti-DIS3L/FITC Conjugated antibody
FITC标记的有丝分裂控制样蛋白DIS3L抗体
| 产品编号 | bs-9052R-FITC |
| 英文名称 | Anti-DIS3L/FITC |
| 中文名称 | FITC标记的有丝分裂控制样蛋白DIS3L抗体 |
| 别 名 | DIS3 like exonuclease 1; DIS3 mitotic control homolog (S. cerevisiae) like; FLJ38088; KIAA1955; MGC4562; DI3L1_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Pig, Horse, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 121kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human DIS3L |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The exosome is a multi-protein complex composed of several highly conserved subunits, some of which are 3’ to 5’ exoribonucleases. The complex is involved in a variety of cellular processes and is responsible for degrading unstable mRNAs that contain AU-rich elements (AREs) in their untranslated 3’ regions. DIS3, also known as RRP44, is a 958 amino acid protein that localizes to both the cytoplasm and the nucleus and contains one PINc domain. Widely expressed with highest expression in testis, DIS3 functions as a component of the exosome exoribonuclease complex and is required for processing of 7S pre-RNA into a mature nuclear complex and, ultimately, for proper mitotic progression. Abnormal expression levels of DIS3 may be associated with colon cancer, suggesting a role for DIS3 in tumorigenesis. Multiple isoforms of DIS3 exist due to alternative splicing events. Function: Putative cytoplasm-specific catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. Subunit: Component of the RNA exosome complex. The catalytically inactive RNA exosome core (Exo-9) complex is believed to associate with catalytic subunits EXOSC10, and DIS3 or DIS3L in cytoplasmic-and nuclear-specific RNA exosome complex forms. Subcellular Location: Cytoplasm. Similarity: Belongs to the RNR ribonuclease family. Database links: Entrez Gene: 115752 Human SwissProt: Q8TF46 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
外泌体是由几个高度保守的亚基组成的多蛋白复合物，其中一些是3’到5’的外核糖核酸酶。该复合物参与多种细胞过程，并负责降解不稳定的mRNA，其中含有富含Au的元素（ARES）在其未翻译的3’区域。DIS3，也称为RRP44，是一种958氨基酸蛋白，定位于细胞质和细胞核，并含有一个PNC结构域。DIS3广泛表达于睾丸中，其作为外泌体外核糖核酸酶复合体的一个组成部分，需要7S预RNA加工成成熟的核复合体，并最终用于适当的有丝分裂进程。DIS3的异常表达水平可能与结肠癌相关，提示DIS3在肿瘤发生中的作用。由于选择性剪接事件，存在多个异构体的DIS3。