分子量:12.4 kDa

纯度:>95% as determined by SDS-PAGE.

内毒素:Less than 1.0 EU per μg of the Human SUMO1, His Tag by the LAL method.

Buffer:50 mM Tris,150 mM NaCl,pH8.0

生物活性:

产品特性:Human SUMO1, His Tag is fused with a polyhistidine tag at the N-terminus, and has a calculated MW of 12.4 kDa. The predicted N-terminus is Met. The reducing (R) protein migrates as 20 kDa in SDS-PAGE .

产品背景:Small ubiquitin-related modifier 1 (SUMO1),a member of the ubiquitin family and SUMO subfamily, is also known as GAP-modifying protein 1 (GMP1), SMT3 homolog 3, ubiquitin-homology domain protein PIC1 and ubiquitin-like protein UBL1,which contains one ubiquitin-like domain. Cleavage of precursor form by SENP1 or SENP2 is necessary for the function of SUMO1. Polymeric SUMO1 chains undergo polyubiquitination by RNF4. SUMO1 may also regulate a network of genes involved in palate development.SUMO1 plays an important role in modulation of NOX activity required for ROS generation.