FITC标记的垂体瘤转化蛋白2抗体
产品名称： FITC标记的垂体瘤转化蛋白2抗体
英文名称： Anti-Securin 2/FITC
产品编号： HZ-19625R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-Securin 2/FITC Conjugated antibody
FITC标记的垂体瘤转化蛋白2抗体
| 英文名称 | Anti-Securin 2/FITC |
| 中文名称 | FITC标记的垂体瘤转化蛋白2抗体 |
| 别 名 | Pituitary tumor transforming 2; Pituitary tumor transforming gene 2 protein; Pituitary tumor-transforming gene 2 protein; PTTG2; PTTG2_HUMAN; Securin-2. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 免疫学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Horse, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 22kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Securin 2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: PTTG is overexpressed in Jurkat and is also detected in human thymus, testis and placenta. PTTG is mainly expressed in the cytoplasm and is also partially localized to the nucleus. Vertebrate PTTG regulates the separin Esp1, which promotes chromatid separation, to overcome the cohesive forces that hold sister chromatids together. This regulatory function of PTTG suggests that defective regulation of cohesion may contribute to cancer by promoting chromosome instability. Although vertebrate PTTG shares cell-cycle functions with its yeast securin counterparts Pds1p and Cut2, none share sequence homology Subunit: Cytoplasm. Nucleus. Tissue Specificity: Expressed at low levels in the pituitary, liver, spleen, prostate, testis, ovary, small intestine and colon. Also expressed in various pituitary, testicular, liver and ovarian tumors. Similarity: Belongs to the securin family. Database links: Entrez Gene: 10744 Human Omim: 604231 Human SwissProt: Q9NZH5 Human Unigene: 668806 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
PtTG在Jurkat中过表达，并在人胸腺、睾丸和胎盘中也检测到。PTTG主要表达于细胞质中，也部分定位于细胞核。脊椎动物PTTG调节促进染色单体分离的分离素Esp1，以克服使姐妹染色单体结合在一起的内聚力。PTTG的这种调节功能提示，内聚力的缺陷调节可能通过促进染色体不稳定性而导致癌症。虽然脊椎动物PTTG与其酵母安全蛋白Pds1p和Cut2具有相同的细胞周期功能，但没有一个具有序列同源性。